Kuijjer Lab

New BioRχiv pre-print

January 06, 2020

We developed PUMA, a network reconstruction algorithm to model miRNA gene regulation, and applied it to 38 tissues from GTEx to identify miRNA functions and associations to disease. For more information, please see the BioRχiv pre-print and the tool.

Using PUMA, we identified tissue-specific regulatory functions of miRNAs. Here, we highlight MIR517C, the miRNA with the highest over-representation of tissue-specific functions, and the functions it regulates in a tissue-specific manner.