Kuijjer Lab

New publication

June 24, 2020

We have a new publication in Cell Reports. We modeled 8,279 individual sample gene regulatory networks representing 29 tissues using PANDA and LIONESS. Using network analysis, we found that gene regulatory processes vary by sex across tissues and that many transcription factors have sex-biased targeting patterns. Differential gene expression between sexes is relatively modest on the non-sex chromosomes, generally occurring in tissues and pathways already known for sex-specific expression. However, we found that gene regulatory differences in male and female participants are widespread. Genes that are differentially regulated between males and females are enriched for disease and tissue-related functions. Please see our publications page for more information.

Graphical abstract of our study.