Together with David Adams' group from the Wellcome Sanger Institute, we used SAMBAR to compare mutational profiles for different mucosal melanoma tissue sites and species in our new publication in Nature Communications. Check it out on our publications page.
We used SAMBAR to de-sparsify somatic mutations into mutations in biological pathways, and
performed principal component regression against phenotypic variables. No significant associations were identified, indicating that tumors arising from different mucosal sites do not represent different mutational subtypes.
